|
Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096
INVENTORS
Ananya Angela Basu
Xiaoyu Zhang*
SHORT DESCRIPTION
A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22
BACKGROUND
Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 2/6/2026
|
Inventor(s):
Keywords(s): AUTM26_1, Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
|