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Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096
INVENTORS
Ananya Angela Basu
Xiaoyu Zhang*
SHORT DESCRIPTION
A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22
BACKGROUND
Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 6/17/2026
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Updated: 3/29/2024
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Inventor(s):
Keywords(s): AUTM26C1, BIO2026, Drug discovery, Proteomics, Small molecule, Targeted therapy, Therapeutics, TPD - Targeted protein degradation
Category(s): Life Sciences > Therapeutics
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