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Methods of Using Modified Cytotoxins to Treat Cancer
NU 2019-135
INVENTORS
Nathan Gianneschi*
SHORT DESCRIPTION
Methods for treating cancers that overexpress fatty acid uptake proteins using small-molecule cytotoxic drugs conjugated to long-chain fatty acid moieties. See also NU2022-111.
BACKGROUND
While prior work (under NU2022-111) demonstrated that lipid-mimicking cytotoxin prodrugs with fatty...
Published: 2/25/2026
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Inventor(s):
Keywords(s): Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION
Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy.
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
Jindan...
Published: 2/24/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Novel Serotonin Receptor Agonist to Treat Neurological Disease
NU 2018-135
INVENTORS
Karl Scheidt*
Adam Csakai
Herbert Meltzer
SHORT DESCRIPTION
A novel small molecule that selectively targets serotonin 5-HT2c receptors for the treatment of psychiatric, mental, and/or neurological diseases.
BACKGROUND
Serotonin is a neurotransmitter known to regulate a variety of neurological functions, and alterations in...
Published: 2/24/2026
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Inventor(s):
Keywords(s): Neurodegenerative disease, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2018-176, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry)
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression of nNOS (e.g., gliomas, ovarian cancer)...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Immunotherapy, Melanoma, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Selective DOT1L Protein Degraders for Precision Cancer Therapy
NU 2022-081
INVENTORS
Sarki Abdulkadir (PI)*
Gary Schiltz (PI)*
SHORT DESCRIPTION
A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate cancer.
BACKGROUND
Current cancer treatments, especially for MLL-rearranged leukemia and prostate cancer, face challenges of off-target effects and...
Published: 2/6/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Leukemia, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101
INVENTORS
Richard Silverman*
Paramita Mukherjee
SHORT DESCRIPTION
This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases.
BACKGROUND
Neurodegenerative disorders such as...
Published: 12/3/2025
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Inventor(s):
Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics
Category(s): Physical Sciences > Materials and Industrial Processes
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Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057
INVENTORS
Hossein Ardehali*
Jason Shapiro
SHORT DESCRIPTION
Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects.
BACKGROUND
Metabolic disorders...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Small Molecule for Bladder Repair
NU 2021-153
INVENTORS
Arun Sharma*
Matthew Bury
Natalie Fuller
SHORT DESCRIPTION
A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue
ABSTRACT
Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
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Nanotherapy to Treat Intestinal Inflammation
NU 2015-160
PRIMARY INVENTOR
Arun Sharma
SHORT DESCRIPTION
Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function
BACKGROUND
Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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MEK7 inhibitors for acute lymphoblastic leukemia (ALL) treatment
NU 2023-060
INVENTORS
Karl Scheidt*
Dalton Kim
Meghan Orr
SHORT DESCRIPTION
Rational design of highly potent and selective covalent MEK7 inhibitors
BACKGROUND
Acute lymphoblastic leukemia (ALL) is a deadly blood cancer, the most common hematological malignancy in patients under 14 years of age. Despite advancements in treatment, ALL relapse...
Published: 12/16/2025
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Inventor(s):
Keywords(s): ALL - Acute Lymphoblastic Leukemia, Cancer/Oncology, Leukemia, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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