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Noninvasive brain-specific inhibition of bone morphogenetic protein signaling for the prevention of tauopathy
NU2025-330
INVENTORS
John Kessler*
Justin Geier
Chian-Yu Peng
SHORT DESCRIPTION
This invention uses a noninvasive gene therapy approach to prevent and treat tauopathies, such as Alzheimer's disease and frontotemporal dementia, by inhibiting bone morphogenetic protein (BMP) specifically within the central nervous system.
BACKGROUND
Tauopathies...
Published: 3/27/2026
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Updated: 3/26/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Gene therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Soft Bio-Integrated Catheter System
NU 2020-150
INVENTORS
John Rogers (Northwestern University, Department of Materials Science and Engineering)*
Igor Efimov (Northwestern University, Department of Biomedical Engineering, Medicine)*
Roozbeh Ghaffari (Northwestern University, Department of Biomedical Engineering)*
Mengdi Han
SHORT DESCRIPTION
This novel catheter platform delivers...
Published: 1/30/2026
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Updated: 11/7/2025
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Inventor(s):
Keywords(s): Gene therapy, Sensors
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244
INVENTORS
Dalton J. Surmeier Jr*
Tatiana Tkatch
Shenyu Zhai
SHORT DESCRIPTION
Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression.
BACKGROUND
Parkinson’s Disease (PD) is the second most common age-related...
Published: 1/5/2026
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Updated: 3/27/2025
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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A novel preparation for ultra-small polymer-grafted nanobins for the targeted delivery of biomedicines
NU 2013-210
INVENTORS
SonBinh Nguyen*
Anthony Chipre
SHORT DESCRIPTION
A method of preparation to increase long-term stability and controlled release for ultra-small polymer-grafted nanobins
BACKGROUND
Small unilamellar vesicles (SUVs) are liposomes in 15 – 50 nm range. These components are of growing interest due to their small size, biocompatibility,...
Published: 11/6/2025
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Updated: 6/2/2023
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Inventor(s):
Keywords(s): Biomedical, Devices, Drug delivery, Gene therapy, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Humanized antibody targeting the tumor associated antigen, IL13Ra2
Humanized antibody targeting the tumor associated antigen, IL13Ra2
NU 2020-031
INVENTORS
Irina Balyasnikova*
SHORT DESCRIPTION
A novel antibody that specifically targets glioblastoma cells
BACKGROUND
Glioblastoma is a deadly, incurable disease with a low 5 year survival rate. The current standard of care typically involves surgical resection...
Published: 3/5/2026
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Updated: 6/1/2023
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Inventor(s):
Keywords(s): Antibody, Cancer/Oncology, CAR T, Cell therapy, Gene therapy, Neurologic disease, Personalized medicine, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
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Gene Therapy for Parkinson's Disease
NU 2021-039
INVENTORS
D. James Surmeier*
Michael Kaplitt
Patricia Gonzalez Rodriguez
SHORT DESCRIPTION
A simple neurological procedure to treat late-stage Parkinson’s Disease patients
BACKGROUND
Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 1/5/2026
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Updated: 5/27/2022
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Inventor(s):
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Potential Treatment Of Corneal Vascularization
NU 2018-012
Inventors
Tsutomu Kume
Short Description
A gene therapy approach to diminish corneal vascularization
Background
Normally devoid of blood vessels, the cornea can become vulnerable to vascularization due to bacterial and viral infections, chemical injury, autoimmune conditions, and post-corneal transplantation, which can lead to...
Published: 11/6/2025
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Updated: 1/15/2019
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Inventor(s):
Keywords(s): Gene therapy, Ophthalmic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Sirt1 Gene Therapy For Improved Wound Healing
NU 2014-173 InventorsMichele JenGuillermo Ameer* Short DescriptionNovel gene therapy delivered from a hydrogel wound dressing (NanonetsTM) augments Sirt1 expression to improve wound healing BackgroundChronic wounds such as non-healing diabetic foot ulcers are a great challenge for the physician and contribute to increasing healthcare costs. Others have...
Published: 11/6/2025
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Updated: 10/27/2018
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Inventor(s):
Keywords(s): Biomedical, Gene therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Novel Gene Delivery Using Self-Assembled Virus-Like Nanoparticles
NU 2011-123 InventorsYves RuffSamuel I. Stupp* Short DescriptionA method of making self-assembled nanostructures for improved gene and siRNA delivery.BackgroundThe use of peptides for the protection and delivery of nucleic acids is a well-established field. Molecular self-assembly has evolved in its capacity to design increasingly complex delivery structures...
Published: 11/6/2025
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Updated: 10/27/2018
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Inventor(s):
Keywords(s): Devices, Gene therapy, Health IT, Medical device, Nanoparticle
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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