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Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION
Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy.
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
Jindan...
Published: 2/24/2026
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Extracellular vesicles for diagnosis and treatment of breast cancer
SHORT DESCRIPTION
Novel methods for detecting cancer through exosome analysis and bioengineered exosomes specifically designed to target cancer stem cells (CSCs).
INVENTORS
Huiping Liu*, MD, PhD
Associate Professor, Pharmacology, Medicine (Hematology and Oncology), Northwestern University Feinberg School...
Published: 2/6/2026
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Inventor(s):
Keywords(s): Biomarker, Breast cancer, Cancer/Oncology, Diagnostics, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Anti-CD73 Monoclonal Antibody for Enhanced Cancer Immunotherapy
NU 2020-207
INVENTORS
Bin Zhang*
Siqi Chen
Jie Fan
SHORT DESCRIPTION
This invention comprises novel anti-CD73 monoclonal antibody compositions that recognize and inhibit mouse and human CD73.
BACKGROUND
CD73, an ecto-enzyme associated with adenosine metabolism, is an emerging immune checkpoint that promotes tumor progression by suppressing...
Published: 12/11/2025
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Inventor(s):
Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Colon cancer, Gastric cancer, Immunotherapy, Lung cancer, Ovarian cancer, Pancreatic cancer, Therapeutics
Category(s): Life Sciences > Therapeutics
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Anti-PODXL Antibody for Inhibiting Metastasis in Breast Cancer
NU 2023-110
INVENTORS
Huiping Liu*
Nurmaa Dashzeveg
SHORT DESCRIPTION
This technology introduces methods of use for an anti-PODXL antibody that effectively prevents and treats metastasis in breast cancer by inhibiting circulating tumor cell (CTC) cluster formation.
BACKGROUND
Cancer metastasis is mediated by circulating tumor cells (CTC) and...
Published: 11/6/2025
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Inventor(s):
Keywords(s): Breast cancer, Cancer/Oncology
Category(s): Life Sciences > Therapeutics
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A Novel Strategy to Block Mitotic Progression for Target Therapy
NU 2019-008
INVENTORS
Yong Wan*
Zhuan Zhou
Junlong Chi
Gary Schiltz
SHORT DESCRIPTION
A novel proteolysis targeting chimera with high in vivo potency against breast cancer
BACKGROUND
Ubiquitination of a protein results in destruction of the protein and, subsequently, the cell itself. A technology known as the proteolysis targeting chimera (PROTAC)...
Published: 12/17/2025
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Inventor(s):
Keywords(s): Breast cancer, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Small Molecules For The Treatment Of Triple-Negative Breast Cancer
NU 2016-100
Inventors
Ali Shilatifard*
Lu Wang
Short Description
Small molecule agonists for the treatment of immunotherapy-resistant triple negative breast cancer (TNBC).
Background
About 10-20% of all breast cancers are triple negative, that is test negative for estrogen and progesterone hormone receptors as well as the HER2 receptor....
Published: 1/15/2026
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Inventor(s):
Keywords(s): Breast cancer, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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