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Polycomb Repressive Complex 1 (PRC1) Inhibitors to Restore Immune Response in B-Cell Lymphomas
SHORT DESCRIPTION
A therapeutic approach that restores MHC-II expression using PRC1 inhibitors to reactivate anti-tumor immunity in B-cell lymphomas.
INVENTORS
Lu Wang*
Zibo Zhao
* Principal Investigator
NU Tech ID: NU 2025-010
IP STATUS
U.S. Provisional Patent Application has been filed.
THERAPEUTICS...
Published: 6/25/2026
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Updated: 6/23/2026
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Inventor(s):
Keywords(s): Cancer/Oncology, Immunotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Peptide Linkers for Modulating Antigen Immune Response in Cancer Vaccines
SHORT DESCRIPTION
A novel non-biologically derived peptide linker technology enabling precise intracellular release of vaccine antigens to enhance immune activation.
NU TECH ID
NU 2024-124
INVENTORS
Chad Mirkin*
Weinberg College of Arts and Sciences, Department of Chemistry
Tanner Fink
*...
Published: 6/16/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): BIO2026, Cancer/Oncology, Immunology, Immunotherapy, Infectious disease, Therapeutics, Vaccine
Category(s): Life Sciences > Therapeutics
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Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease
SHORT DESCRIPTION
Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders.
INVENTORS
Colby Thaxton*
Northwestern...
Published: 7/1/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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Retargetable and Metabolically Tunable CAR Cell Platforms for Durable, Antigen‑Specific Cancer Therapy
SHORT DESCRIPTION
A modular immunotherapy platform that combines hapten‑redirectable chimeric antigen receptor (CAR) constructs with itaconate‑programmed, memory‑like immune cells to deliver safer, more durable, and tunable antigen‑specific responses across hematologic and solid tumors.
NU TECH ID
NU 2023-021B
INVENTORS
Ashima...
Published: 7/8/2026
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Updated: 6/10/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cancer Treatment, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Inflammation, Leukemia, Lymphoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance
SHORT DESCRIPTION
A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance.
INVENTORS
Edward Thorp*
Northwestern University Feinberg School of Medicine, Department of Pathology
Evan Scott*
McCormick School of Engineering, Department...
Published: 6/16/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): BIO2026, Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation
Category(s): Life Sciences > Therapeutics
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Targeting Autoimmunity-Associated T cells via AHR Pathway Control
SHORT DESCRIPTION
Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity.
INVENTORS
Jaehyuk Choi*
Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)**
Deepak Rao
Brigham and Women's...
Published: 6/16/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Autoimmune disease, BIO2026, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 6/16/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, BIO2026, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160
INVENTORS
Jason Miska*
Feinberg School of Medicine, Department of Neurological Surgery
Peng Zhang*
Feinberg School of Medicine, Department of Neurological Surgery
SHORT DESCRIPTION
Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM.
BACKGROUND
Glioblastoma...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Adjunct therapy, BIO2026, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Nucleic Acids, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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SEC61 Complex as a Novel Therapeutic Target to Enhance Immunotherapy Response in Glioblastoma
NU 2023-011
INVENTORS
Irina Balyasnikova*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
Joseph Duffy
SHORT DESCRIPTION
A targeted therapeutic approach that inhibits the SEC61 complex to enhance responses to immunotherapy in glioblastoma.
BACKGROUND
Glioblastoma (GBM) is the most aggressive primary...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): BIO2026, Brain cancer, Cancer/Oncology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Anti-TYRP1 Bi-specific T cell Engager for Treatment of TYRP1-expressing melanoma
NU 2022-123
INVENTORS
Irina Balyasnikova (Feinberg School of Medicine, Department of Neurological Surgery)*
Isabelle Le Poole (Feinberg School of Medicine, Department of Dermatology)*
SHORT DESCRIPTION
A bispecific T cell engager that targets CD3+ T cells and TYRP1-expressing melanoma cells.
BACKGROUND
Melanoma is the deadliest form of skin...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): BIO2026, Biologic, Cancer/Oncology, Immunotherapy, Melanoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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