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Antibodies for treatment of coronavirus disease
NU 2023-247
INVENTORS
Huiping Liu*
Deyu Fang*
Hannah Mubarak
Andrew Hoffmann
Nurmaa Dashzeveg
Lamiaa El-Shennawy
Juncheng Wei
Wuwei Tan
Yang Shen
SHORT DESCRIPTION
Computationally redesigned antibodies targeting SARS-CoV-2 for treating COVID-19.
BACKGROUND
The continuous evolution of SARS-CoV-2 has allowed the virus to escape most therapeutic...
Published: 2/26/2026
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Updated: 2/26/2026
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Inventor(s):
Keywords(s): Antibody, Artificial Intelligence & Machine Learning, Biologic, Infectious disease, Research tool, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146
INVENTORS
Jennifer Wu*
SHORT DESCRIPTION
A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer.
BACKGROUND
Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 4/9/2026
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Updated: 12/3/2025
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Inventor(s):
Keywords(s): Antibody, Biologic, Cancer/Oncology, Immunotherapy, Infectious disease, Research tool, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy
NU NUMBER NU 2020-145
INVENTORS
Deyu Fang*
Huiping Liu*
Andrew Hoffmann
Emma June Schuster
Lamiaa El-Shennawy
Nurmaa Dashzeveg
SHORT DESCRIPTION
This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19.
BACKGROUND
The COVID-19...
Published: 4/13/2026
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Updated: 11/17/2025
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Inventor(s):
Keywords(s): COVID-19, Drug delivery, Infectious disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Methods for assembling peptides into peptide amphiphile nanofibers
TITLE: Peptide Nanofiber Assembly for Enhanced Therapeutic Delivery
NU 2020-081
SHORT DESCRIPTION
This technology uses self-assembling peptide amphiphile nanofibers to protect and deliver therapeutic peptides. It reduces degradation and improves delivery efficiency for advanced treatment applications.
BACKGROUND
Peptide therapeutics offer promise...
Published: 1/9/2026
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Updated: 10/21/2025
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Inventor(s):
Keywords(s): Brain injury, Drug delivery, Infectious disease, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, Neurovascular, Therapeutics
Category(s): Life Sciences > Therapeutics
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Self-powered, bioresorbable drug release systems
NU 2023-045
INVENTORS
John Rogers*
Colin Franz*
Yamin Zhang
SHORT DESCRIPTION
Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment.
BACKGROUND
Current drug delivery systems...
Published: 11/6/2025
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Updated: 5/8/2025
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Inventor(s):
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Compositions and Methods for the Treatment of Intestinal Inflammation
NU 2021-252
INVENTORS
Matthew Bury
Muthukumar Gunasekaran
Sunjay Kaushal
Arun Sharma*
Tiffany Sharma
BACKGROUND
Crohn’s Disease (CD) is partly caused by a highly pro-inflammatory lesion microenvironment which subsequently causes numerous clinical complications. Northwestern University scientists have developed a method to control...
Published: 3/17/2026
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Updated: 2/25/2025
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cell therapy, IBD - Inflammatory bowel disease, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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TGF-beta Inhibitor for Reversing HIV Latency
NU 2022-207
INVENTORS
Elena Martinelli*
SHORT DESCRIPTION
A method for activating latent immunodeficiency virus infections using a TGF-beta inhibitor in order to treat HIV.
BACKGROUND
Current HIV treatments focus on inhibiting viral replication but fail to address latent HIV reservoirs, which pose a risk of reactivation and disease progression....
Published: 4/13/2026
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Updated: 2/17/2025
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Inventor(s):
Keywords(s): Adjunct therapy, Infectious disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Antibody-based HPV detection
NU 2023-157
INVENTORS
Laimonis Laimins*
Conor Templeton
SHORT DESCRIPTION
High-risk human papillomaviruses (HPV) are a primary cause of genital and oropharyngeal cancers. Nucleic acid amplification tests (NAATs) are the current standard in the field for robust identification and genotyping of HPV infections. For more simplistic staining,...
Published: 12/10/2025
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Updated: 1/30/2025
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Inventor(s):
Keywords(s): Diagnostics, Infectious disease
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
NU 2022-192
INVENTORS
Neha P. Kamat*
Vivian Hu
BACKGROUND
Virus infection posts a recurring global health challenge, and vaccines remain an effective protective against virus threats. However, many current vaccines face limitations including potential conversion of inactivated virus into pathogenic virus, immunogenicity of recombinant...
Published: 4/10/2026
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Updated: 10/17/2024
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Inventor(s):
Keywords(s): Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Methods and Compounds that block the release of enveloped viruses from cells
NU 2019-084
INVENTORS
Jonathan Leis*
Chi-Hao Luan
SHORT DESCRIPTION
Antiviral agents targeting a broad range of enveloped viruses for pan-viral therapeutics
BACKGROUND
To date, there are very few shared mechanisms identified between families of shared viruses. As such, there is minimal development of a broad-spectrum antiviral. Enveloped viruses...
Published: 11/6/2025
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Updated: 6/2/2023
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Inventor(s):
Keywords(s): Immunology, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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