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Bioactive Supramolecular Peptide Amphiphile Platforms for CNS In Vitro Models, CNS Regeneration, and Neurotherapeutic Delivery
SHORT DESCRIPTION
A suite of self‑assembling peptide amphiphile nanostructures and hydrogels that mimic key neurotrophic factors, modulate ionic and electrical microenvironments, and protect therapeutic peptides to enhance neural survival, maturation, and regeneration across CNS diseases and injuries
INVENTORS
Samuel I Stupp
Weinberg...
Published: 7/1/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, BIO2026, Biomaterials, CNS - Central Nervous System, Drug delivery, Drug discovery, Drug screening, Hydrogel, In vitro models, Neurology, PD - Parkinson's Disease, Regenerative medicine, Research tool, Scaffold, SCI - Spinal cord injury, Smart/Functional materials, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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GDNF-Mimetic Self-Assembling Supramolecular Nanostructure to Enhance Survival and Function of Dopaminergic Neurons for Treatment of Parkinson's Disease
NU 2024-175
SHORT DESCRIPTION
A self-assembling bioactive matrix that presents GDNF-mimetic peptides to support the viability, maturation, and function of dopaminergic neurons in cell replacement therapy for treatment of Parkinson’s Disease.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department...
Published: 6/16/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): BIO2026, Biologic, Biomaterials, Cell delivery, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Scaffold, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology
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Targeted Nanofiber Therapy for Atherosclerosis – Enhanced Plaque Regression via Precise Drug Delivery
SHORT DESCRIPTION
Nanofiber-based drug delivery system that targets atherosclerotic plaque and delivers a therapeutic agent locally to induce plaque regression for management of cardiovascular disease.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
* Principal Investigator
NU...
Published: 6/16/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): Atherosclerosis, BIO2026, Biomaterials, Cardiology and Cardiovascular disease, Drug delivery, Nanomaterials, Nanotechnology, Self-assembly, Smart/Functional materials, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bioactive, Conductive, and Antioxidant Supramolecular Polymer Hydrogels for Neural Applications
SHORT DESCRIPTION
Biomaterial scaffold for neural cell culture and therapeutic implants that harnesses bioactive, conductive, and antioxidant properties to boost neural cell viability and maturation.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
Anna Metlushko
Bo...
Published: 6/16/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): BIO2026, Biologic, Biomaterials, CNS - Central Nervous System, Implantable devices, Neurology, Regenerative medicine, Scaffold, SCI - Spinal cord injury, Smart/Functional materials
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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Self-powered, bioresorbable drug release systems
NU 2023-045
INVENTORS
John Rogers*
Colin Franz*
Yamin Zhang
SHORT DESCRIPTION
Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment.
BACKGROUND
Current drug delivery systems...
Published: 11/6/2025
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Updated: 5/8/2025
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Inventor(s):
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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Sliding Bioactive Peptides for Therapeutic Delivery in CNS Regeneration
NU 2023-142
INVENTORS
Samuel I. Stupp*
Federico Lancia
Madison E. Strong
Matias A. Alvarez-Saavedra
SHORT DESCRIPTION
This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 6/16/2026
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Updated: 5/2/2025
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Inventor(s):
Keywords(s): BIO2026, Biomaterials, CNS - Central Nervous System, Drug delivery, Neurologic disease, Neurology, Regenerative medicine, SCI - Spinal cord injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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Ion-Doped Supramolecular Nanostructures
NU 2023-006
INVENTORS
Samuel Stupp*
Zaida Alvarez Pinto
Ivan Ramos Sasselli
Nicholas Allen Sather
Zois Syrgiannis
SHORT DESCRIPTION
This technology involves the development of ion-doped peptide amphiphiles (IDPAs) that form supramolecular nanostructures capable of enhancing neural development and membrane excitability...
Published: 6/16/2026
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Updated: 2/18/2025
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Inventor(s):
Keywords(s): BIO2026, Biomaterials, Drug delivery, Nanomaterials
Category(s): Physical Sciences > Materials and Industrial Processes
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Peptide Amphiphiles for Sonic Hedgehog Regulation of Pelvic Nerves for Treatment of Stress Urinary Incontinence and Erectile Dysfunction
NU 2018-075, 2018-076, 2018-077
INVENTORS
Caroline Podlasek
Kevin McVary
Daniel Harrington
Samuel Stupp*
SHORT DESCRIPTION
Novel peptide amphiphile (PA) nanofiber hydrogel is used to deliver sonic hedgehog (SHH) protein to nerves of the major pelvic ganglia and the rhabdospincter as a treatment for erectile dysfunction and urinary incontinence.
...
Published: 11/6/2025
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Updated: 7/11/2024
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Inventor(s):
Keywords(s): Biomaterials, Drug delivery, Materials, Therapeutics
Category(s): Life Sciences > Therapeutics
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Aqueous Peptide Programming of Organic Ferroelectric Materials
NU2023-005
INVENTORS
Samuel Stupp*
Yang Yang
SHORT DESCRIPTION
Novel peptide material with precise nanoscale assembly, versatility in morphology, enhanced ferroelectric properties, high-temperature and electrochemical performance.
BACKGROUND
Poly(vinylidene fluoride) (PVDF) is the leading organic ferroelectric material with multiaxial ferroelectricity,...
Published: 11/6/2025
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Updated: 7/9/2024
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Inventor(s):
Keywords(s): Biomaterials, Materials
Category(s): Physical Sciences > Materials and Industrial Processes
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Nanopatterning for control of cell cytoskeleton
NU 2018-027
INVENTORS
Chad Mirkin*
Milan Mrksich*
Brian Meckes
Maria Cabezas
SHORT DESCRIPTION
Polymer pen lithography (PPL) to spatially define locations where cells can adhere to a substrate in aniosotropic patterns.
BACKGROUND
Cells have unique shapes that play significant roles in their function; cell shape influences cellular processes...
Published: 11/6/2025
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Updated: 7/3/2024
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Inventor(s):
Keywords(s): Biomaterials, Therapeutics
Category(s): Life Sciences > Therapeutics
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