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Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION
A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure.
INVENTORS
Elizabeth...
Published: 5/15/2026
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Updated: 5/12/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bioactive, Conductive, and Antioxidant Supramolecular Polymer Hydrogels for Neural Applications
SHORT DESCRIPTION
Biomaterial scaffold for neural cell culture and therapeutic implants that harnesses bioactive, conductive, and antioxidant properties to boost neural cell viability and maturation.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
Anna Metlushko
Bo...
Published: 5/11/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): Biologic, Biomaterials, CNS - Central Nervous System, Implantable devices, Neurology, Regenerative medicine, Scaffold, SCI - Spinal cord injury, Smart/Functional materials
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION
Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs.
INVENTORS
Youyang Zhao*
Ann & Robert H Lurie Children's Hospital of Chicago
* Principal Investigator
NU...
Published: 5/8/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
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Netrin-1 Mimetic Peptide Amphiphile Assemblies for Enhanced CNS Regeneration
NU 2024-174
INVENTORS
Samuel Stupp*
Cara Smith
Zaida Alvarez Pinto
SHORT DESCRIPTION
Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration.
BACKGROUND
Neurotrophic factors are essential for the development and regeneration of neurons; however,...
Published: 5/11/2026
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Updated: 2/20/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Nanotechnology, Neurodegenerative disease, Regenerative medicine, SCI - Spinal cord injury, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Sliding Bioactive Peptides for Therapeutic Delivery in CNS Regeneration
NU 2023-142
INVENTORS
Samuel I. Stupp*
Federico Lancia
Madison E. Strong
Matias A. Alvarez-Saavedra
SHORT DESCRIPTION
This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 5/11/2026
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Updated: 5/2/2025
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Inventor(s):
Keywords(s): Biomaterials, CNS - Central Nervous System, Drug delivery, Neurologic disease, Neurology, Regenerative medicine, SCI - Spinal cord injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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Genetic circuits for engineering hypoxia-responsive cellular functions
NU 2021-259
INVENTORS
Joshua Leonard*
Patrick Donahue
SHORT DESCRIPTION
A customizable DNA based biosensor for detecting hypoxic environments
BACKGROUND
Cell-based therapies have been successful in treating many malignancies, leading to substantial increases in patient survival. However, translating these successes to the treatment of solid...
Published: 4/9/2026
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Updated: 1/28/2025
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Inventor(s):
Keywords(s): Biosensors, Cancer/Oncology, CVA - Cerebrovascular Accident, Regenerative medicine, Research tool, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Reelin for the Clinical Treatment of Cardiac Pathologies
NU 2020-159
INVENTORS
Guillermo Oliver*
Xialoei Liu
SHORT DESCRIPTION
A novel approach to treating cardiovasculature disease
BACKGROUND
Although little is known about the role of cardiac lymphatics in the healthy or failing heart, a growing body of evidence indicates that improved cardiac lymphatic vessel growth and function could be a novel therapeutic...
Published: 5/8/2026
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Updated: 8/10/2021
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Inventor(s):
Keywords(s): Biologic, Cardiology and Cardiovascular disease, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
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