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Bioactive Supramolecular Peptide Amphiphile Platforms for CNS In Vitro Models, CNS Regeneration, and Neurotherapeutic Delivery
SHORT DESCRIPTION
A suite of self‑assembling peptide amphiphile nanostructures and hydrogels that mimic key neurotrophic factors, modulate ionic and electrical microenvironments, and protect therapeutic peptides to enhance neural survival, maturation, and regeneration across CNS diseases and injuries
INVENTORS
Samuel I Stupp
Weinberg...
Published: 6/16/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, BIO2026, Biomaterials, CNS - Central Nervous System, Drug delivery, Drug discovery, Drug screening, Hydrogel, In vitro models, Neurology, PD - Parkinson's Disease, Regenerative medicine, Research tool, Scaffold, SCI - Spinal cord injury, Smart/Functional materials, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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Novel Aminotransferase Inhibitor Platform for the Treatment of Cancer and Neurological Disorders
SHORT DESCRIPTION
Novel Aminotransferase Mechanism-Based Inhibitor (MBI) Platform Targeting OAT and GABA-AT as Novel Treatments for Cancer and Neurological Disorders.
INVENTORS
Richard Silverman*
Weinberg College of Arts and Sciences, Department of Chemistry
* Principal Investigator
DEVELOPMENT...
Published: 6/17/2026
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Updated: 6/1/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, BIO2026, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Epilepsy, Gastric cancer, Liver cancer, Lung cancer, Neurodegenerative disease, Neurologic disease, Neurology, Pancreatic cancer, PD - Parkinson's Disease, Psychiatric disorder, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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GDNF-Mimetic Self-Assembling Supramolecular Nanostructure to Enhance Survival and Function of Dopaminergic Neurons for Treatment of Parkinson's Disease
NU 2024-175
SHORT DESCRIPTION
A self-assembling bioactive matrix that presents GDNF-mimetic peptides to support the viability, maturation, and function of dopaminergic neurons in cell replacement therapy for treatment of Parkinson’s Disease.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department...
Published: 6/16/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): BIO2026, Biologic, Biomaterials, Cell delivery, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Scaffold, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology
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Bioactive, Conductive, and Antioxidant Supramolecular Polymer Hydrogels for Neural Applications
SHORT DESCRIPTION
Biomaterial scaffold for neural cell culture and therapeutic implants that harnesses bioactive, conductive, and antioxidant properties to boost neural cell viability and maturation.
INVENTORS
Samuel Stupp*
Weinberg College of Arts and Sciences, Department of Chemistry
Anna Metlushko
Bo...
Published: 6/16/2026
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Updated: 4/30/2026
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Inventor(s):
Keywords(s): BIO2026, Biologic, Biomaterials, CNS - Central Nervous System, Implantable devices, Neurology, Regenerative medicine, Scaffold, SCI - Spinal cord injury, Smart/Functional materials
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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Inhibitors of MNK Kinase for Targeted Cancer and CNS Therapeutics
NU 2015-098 (NU 2015-098, NU 2018-036, NU 2025-036)
INVENTORS
Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)*
SHORT DESCRIPTION
MNK kinase inhibitors that reduce cancer cell viability and proliferation and penetrates the brain for potential treatment of glioblastoma and CNS disorders.
BACKGROUND
Leukemia and brain...
Published: 6/16/2026
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Updated: 4/29/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, AML - Acute myeloid leukemia, ASD - Autism Spectrum Disorder, BIO2026, Bladder cancer, Brain cancer, Breast cancer, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Lung cancer, Neurodegenerative disease, Pancreatic cancer, Prostate cancer, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 6/16/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, BIO2026, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Selective PAD2 Inhibitors for Neuroprotection in Traumatic Brain Injury
SHORT DESCRIPTION
Novel PAD2-selective inhibitor platform targeting neuroinflammation to support both acute neuroprotection and long-term functional recovery as a first-in-class treatment of traumatic brain injury.
INVENTORS
Hasan Alam*
Northwestern University Feinberg School of Medicine, Department of Surgery (Trauma...
Published: 6/16/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): BIO2026, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Neurodegenerative disease, Neuroinflammation, Neurologic disease, Neurology, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160
INVENTORS
Jason Miska*
Feinberg School of Medicine, Department of Neurological Surgery
Peng Zhang*
Feinberg School of Medicine, Department of Neurological Surgery
SHORT DESCRIPTION
Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM.
BACKGROUND
Glioblastoma...
Published: 6/16/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Adjunct therapy, BIO2026, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Nucleic Acids, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
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Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098
Inventors
Leonidas C. Platanias*
Gary E. Schiltz
Rama K. Mishra
Short Description
A small molecule to treat glioblastoma multiforme by blocking the Mnk pathway.
Background
Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed...
Published: 6/16/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, BIO2026, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, GBM - Glioblastoma, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Netrin-1 Mimetic Peptide Amphiphile Assemblies for Enhanced CNS Regeneration
NU 2024-174
INVENTORS
Samuel Stupp*
Cara Smith
Zaida Alvarez Pinto
SHORT DESCRIPTION
Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration.
BACKGROUND
Neurotrophic factors are essential for the development and regeneration of neurons; however,...
Published: 6/16/2026
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Updated: 2/20/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, BIO2026, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Nanotechnology, Neurodegenerative disease, Regenerative medicine, SCI - Spinal cord injury, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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