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CD73-PROTACs for Cancer Therapy
SHORT DESCRIPTION
A novel first-in-class proteolysis targeting chimera (PROTAC) that selectively degrades CD73 to reverse tumor immune evasion and inhibit cancer progression.
INVENTORS
Bin Zhang*
Northwestern University Feinberg School of Medicine, Department of Medicine (Hematology & Oncology)
Gary Schiltz*
Weinberg...
Published: 7/6/2026
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Updated: 7/6/2026
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Inventor(s):
Keywords(s): BIO2026, Breast cancer, Cancer/Oncology, Colon cancer, Lung cancer, Melanoma, PROTAC, Targeted therapy, Therapeutics, TPD - Targeted protein degradation
Category(s): Life Sciences > Therapeutics
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Polycomb Repressive Complex 1 (PRC1) Inhibitors to Restore Immune Response in B-Cell Lymphomas
SHORT DESCRIPTION
A therapeutic approach that restores MHC-II expression using PRC1 inhibitors to reactivate anti-tumor immunity in B-cell lymphomas.
INVENTORS
Lu Wang*
Zibo Zhao
* Principal Investigator
NU Tech ID: NU 2025-010
IP STATUS
U.S. Provisional Patent Application has been filed.
THERAPEUTICS...
Published: 6/25/2026
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Updated: 6/23/2026
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Inventor(s):
Keywords(s): Cancer/Oncology, Immunotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Compositions and Methods for Enhanced Mitochondrial Delivery for Regenerative Therapies
SHORT DESCRIPTION
A novel peptide coating process that improves mitochondrial cell uptake, preserves function, and enables targeted delivery for cardiovascular and regenerative therapies.
NU Tech ID
NU 2025-055
INVENTORS
Bin Jiang*
Northwestern University Feinberg School of Medicine, Department of Surgery (Vascular...
Published: 6/18/2026
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Updated: 6/18/2026
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Inventor(s):
Keywords(s): BIO2026, Cardiology and Cardiovascular disease, MI - Myocardial Infarction, Neurodegenerative disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease, Vascular repair
Category(s): Life Sciences > Therapeutics
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FTY720 for Treatment of Marfan Syndrome
NU2025-219
INVENTORS
Tsutomu Kume*
Can Tan
SHORT DESCRIPTION
This invention provides a novel use for FTY720, also known as Fingolimod, for the treatment and prevention of myxomatous degeneration of the mitral valve (MDMV) in Marfan syndrome.
BACKGROUND
Marfan syndrome, a genetic connective tissue disorder, frequently leads to MDMV, a severe...
Published: 6/18/2026
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Updated: 6/18/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
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Inhibitors of TRIP8b for Novel Mood Disorder Therapeutics
SHORT DESCRIPTION
Novel inhibitors that disrupt TRIP8b-HCN binding to offer an alternative antidepressant mechanism for treatment of mood disorders.
INVENTORS
Gary Schiltz*
Weinberg College of Arts and Sciences, Department of Chemistry
Dane Chetkovich
Ye Han
Iredia Iyamu
Kyle Lyman
*...
Published: 6/17/2026
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Updated: 6/17/2026
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Inventor(s):
Keywords(s): Antidepressant, BIO2026, Depression, Mood disorder, Neurologic disease, Neurology, Psychiatric disorder, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Bioactive Supramolecular Peptide Amphiphile Platforms for CNS In Vitro Models, CNS Regeneration, and Neurotherapeutic Delivery
SHORT DESCRIPTION
A suite of self‑assembling peptide amphiphile nanostructures and hydrogels that mimic key neurotrophic factors, modulate ionic and electrical microenvironments, and protect therapeutic peptides to enhance neural survival, maturation, and regeneration across CNS diseases and injuries
INVENTORS
Samuel I Stupp
Weinberg...
Published: 7/1/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, BIO2026, Biomaterials, CNS - Central Nervous System, Drug delivery, Drug discovery, Drug screening, Hydrogel, In vitro models, Neurology, PD - Parkinson's Disease, Regenerative medicine, Research tool, Scaffold, SCI - Spinal cord injury, Smart/Functional materials, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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Protein Degraders of NSD2 for Targeted Treatment of Head and Neck Cancers
SHORT DESCRIPTION
Targeted protein degraders that selectively eliminate NSD2 for improved treatment of head and neck cancers.
INVENTORS
Gary Schiltz*
Weinberg College of Arts and Sciences, Department of Chemistry
Yanis Boumber
* Principal Investigator
NU Tech ID: NU 2023-140
IP STATUS
U.S....
Published: 6/16/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): BIO2026, Cancer/Oncology, Head and neck cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2016-137B
INVENTORS
Richard Silverman
Weinberg College of Arts and Sciences, Department of Chemistry
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression of nNOS (e.g., gliomas, ovarian cancer) as well as neurodegenerative...
Published: 6/17/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, BIO2026, Cancer/Oncology, HD - Huntington's Disease, Melanoma, Neurodegenerative disease, Neuroinflammation, Neurologic disease, nNOS, PD - Parkinson's Disease, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Peptide Linkers for Modulating Antigen Immune Response in Cancer Vaccines
SHORT DESCRIPTION
A novel non-biologically derived peptide linker technology enabling precise intracellular release of vaccine antigens to enhance immune activation.
NU TECH ID
NU 2024-124
INVENTORS
Chad Mirkin*
Weinberg College of Arts and Sciences, Department of Chemistry
Tanner Fink
*...
Published: 6/16/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): BIO2026, Cancer/Oncology, Immunology, Immunotherapy, Infectious disease, Therapeutics, Vaccine
Category(s): Life Sciences > Therapeutics
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Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease
SHORT DESCRIPTION
Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders.
INVENTORS
Colby Thaxton*
Northwestern...
Published: 7/1/2026
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Updated: 6/16/2026
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Inventor(s):
Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
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