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Safe, Automated, And High Yielding Method For Synthesizing Deoxyoligonucleicguanidines (DNG) Strands
NU 2019-109
SHORT DESCRIPTION
Spherical nucleic acids (SNAs) incorporating deoxynucleic guanidine (DNG)-modified oligonucleotides enable improved cellular uptake and intracellular delivery by introducing positively charged backbone modifications.
BACKGROUND
Oligonucleotide therapeutics, including antisense and RNA interference (RNAi) approaches,...
Published: 5/21/2026
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Updated: 5/18/2026
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Inventor(s):
Keywords(s): Drug delivery, Nucleic Acids, Platform technology, Research tool
Category(s): Life Sciences > Therapeutics
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Northwestern Startup: Syenex, Inc.
Northwestern Inventor:
Joshua Leonard
McCormick School of Engineering
Chemical and Biological Engineering
Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...
Published: 5/5/2026
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Updated: 5/5/2026
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Inventor(s):
Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
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Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION
A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets.
INVENTORS
Shana Kelley*
Weinberg College of Arts & Sciences, Department of Chemistry
Yi Li
* Principal Investigator
NU Tech ID: NU 2025-050
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Smart Memtransistors: Learning to Forget On Demand
NU 2021-179
PRIMARY INVENTOR
Jiangtan Yuan
Stephanie Elizabeth Liu
Vinod Kumar Sangwan
Amit R. Trivedi
Mark C. Hersam*
SHORT DESCRIPTION
A reconfigurable memtransistor that can dynamically adapt to new learning tasks
BACKGROUND
Recent AI advances have been possible due to GPU enabled parallel computing. However, this high computing capacity is not...
Published: 11/6/2025
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Updated: 12/17/2021
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Inventor(s):
Keywords(s): Artificial Intelligence & Machine Learning, Computer hardware, Data processing/analysis, Data storage, Electronics & Circuits, Nanotechnology, Platform technology, Quantum computing, Semiconductors & Integrated Circuits
Category(s): Physical Sciences > Materials and Industrial Processes, Physical Sciences > Engineering & Technology
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Megamolecule Synthetic Antibodies
NU 2016-048
Inventors
Milan Mrksich*
Justin Modica
Short Description
A novel method to join antibody fragments to produce megamolecule antibody-like drugs
Abstract
Northwestern researchers have developed a novel Lego-like platform to build megamolecule antibodies whose fragments can be customized for particular targets. The development...
Published: 4/8/2026
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Updated: 10/27/2018
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Inventor(s):
Keywords(s): Antibody, Biologic, Platform technology, Therapeutics
Category(s): Life Sciences > Therapeutics
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