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Synthetic Receptors for IL-23
NU 2024-093
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
NU 2024-047
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038)
INVENTORS
Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry)
SHORT DESCRIPTION
Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 4/14/2026
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Updated: 4/1/2026
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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A Rat Model of IgA Nephropathy
NU 2019-196
INVENTORS
Jing Jin*
Xinfang Xie
SHORT DESCRIPTION
A novel rat model of IgA nephropathy (IgAN, also known as Berger's disease), enabling reproducible kidney mesangial deposits characteristic of the human disease for therapeutic and diagnostic evaluation.
BACKGROUND
IgAN, the most common glomerulonephritis worldwide, results...
Published: 4/13/2026
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Updated: 2/26/2026
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Inventor(s):
Keywords(s): Animal Model, Antibody, Drug screening, Immunology, Inflammation, Renal Disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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A platform for mapping reactive cysteines within the immunopeptidome
NU 2024-044
INVENTORS
Xiaoyu Zhang*
Chenlu Zhang
Chen Zhou
SHORT DESCRIPTION
This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome.
BACKGROUND
The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 12/11/2025
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Updated: 10/31/2025
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Inventor(s):
Keywords(s): Biomarker, Immunology, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes
NU 2022-192
INVENTORS
Neha P. Kamat*
Vivian Hu
BACKGROUND
Virus infection posts a recurring global health challenge, and vaccines remain an effective protective against virus threats. However, many current vaccines face limitations including potential conversion of inactivated virus into pathogenic virus, immunogenicity of recombinant...
Published: 4/10/2026
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Updated: 10/17/2024
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Inventor(s):
Keywords(s): Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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CAR T Cells Armored with IL15 for Treating Glioblastoma
NU 2022-074
INVENTORS
Irina V. Balyasnikova*
BACKGROUND
Glioblastoma is a devastating brain cancer for which no effective treatment exists, leading to short patient survival. Although investigations are underway to explore chimeric antigen receptor T (CAR-T) cells as glioblastoma therapy, the immunosuppressive tumor microenvironment (TME)...
Published: 4/9/2026
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Updated: 10/17/2024
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Inventor(s):
Keywords(s): Brain cancer, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Methods and Compounds that block the release of enveloped viruses from cells
NU 2019-084
INVENTORS
Jonathan Leis*
Chi-Hao Luan
SHORT DESCRIPTION
Antiviral agents targeting a broad range of enveloped viruses for pan-viral therapeutics
BACKGROUND
To date, there are very few shared mechanisms identified between families of shared viruses. As such, there is minimal development of a broad-spectrum antiviral. Enveloped viruses...
Published: 11/6/2025
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Updated: 6/2/2023
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Inventor(s):
Keywords(s): Immunology, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Clotrimazole as a treatment for immunodeficiency disorders
NU 2020-021
INVENTORS
Hossein Ardehali*
Adam De Jesus
SHORT DESCRIPTION
A drug that elicits inflammatory response as a therapeutic for immunodeficiency disorders
ABSTRACT
The primary hallmarks of Immunodeficiency disorders include suppression of the immune system and impaired response to infection, which can be fatal. There is currently a lack of...
Published: 3/31/2026
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Updated: 4/26/2023
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Inventor(s):
Keywords(s): Immunodeficiency, Immunology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Immuno-Ablation Agent for Combination Therapy Against Solid Tumors
NU 2022-058
INVENTORS
Dong Hyun Kim*
Kijung Kwak
Bo Yu
SHORT DESCRIPTION
A method of co-delivering immune modulating agents during ethanol ablation of solid tumors
BACKGROUND
Ethanol ablation therapy is a simple and inexpensive method commonly employed to shrink solid tumors. Like other tumor ablation techniques, such as radiofrequency ablation,...
Published: 11/6/2025
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Updated: 6/22/2022
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Inventor(s):
Keywords(s): Cancer/Oncology, Drug delivery, Immunology, Immunotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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