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Orthogonal Synthetic Receptors for IL-23
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William Corcoran
...
Published: 5/8/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 5/11/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Compositions and Methods for the Treatment of Intestinal Inflammation
NU 2021-252
INVENTORS
Matthew Bury
Muthukumar Gunasekaran
Sunjay Kaushal
Arun Sharma*
Tiffany Sharma
BACKGROUND
Crohn’s Disease (CD) is partly caused by a highly pro-inflammatory lesion microenvironment which subsequently causes numerous clinical complications. Northwestern University scientists have developed a method to control...
Published: 3/17/2026
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Updated: 2/25/2025
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cell therapy, IBD - Inflammatory bowel disease, Immunotherapy, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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