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Synthetic Receptors for IL-23
NU 2024-093
SHORT DESCRIPTION
Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions.
INVENTORS
Joshua Leonard*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Aaron Morris
William...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
NU 2024-047
SHORT DESCRIPTION
An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares.
INVENTORS
Arthur Prindle*
McCormick School of Engineering, Department of Chemical and Biological Engineering
Jonathan...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Recombinant Annexin Therapy for Muscle, Cardiac, and Neuronal Cell Membrane Repair
NU 2022-008
SHORT DESCRIPTION
An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce skeletal muscle, cardiac, and neuronal cell death and preserve tissue function.
INVENTORS
INVENTORS
Elizabeth McNally*
Feinberg School of Medicine, Department of Medicine (Cardiology...
Published: 4/14/2026
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Updated: 4/14/2026
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Inventor(s):
Keywords(s): Biologic, Cardiomyopathy, DMD - Duchenne muscular dystrophy, Inflammation, Membrane injury and repair, Neurodegenerative disease, Rare diseases, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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A Rat Model of IgA Nephropathy
NU 2019-196
INVENTORS
Jing Jin*
Xinfang Xie
SHORT DESCRIPTION
A novel rat model of IgA nephropathy (IgAN, also known as Berger's disease), enabling reproducible kidney mesangial deposits characteristic of the human disease for therapeutic and diagnostic evaluation.
BACKGROUND
IgAN, the most common glomerulonephritis worldwide, results...
Published: 4/13/2026
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Updated: 2/26/2026
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Inventor(s):
Keywords(s): Animal Model, Antibody, Drug screening, Immunology, Inflammation, Renal Disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Nanotherapy to Treat Intestinal Inflammation
NU 2015-160
PRIMARY INVENTOR
Arun Sharma
SHORT DESCRIPTION
Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function
BACKGROUND
Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 11/6/2025
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Updated: 2/25/2025
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Inventor(s):
Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Self-assembling peptides with hyaluronic acid binding domains to form hydrogels
NU 2022-016
INVENTORS
Kyle M. Koss
Terrance J. Sereda*
Jason A. Wertheim*
ABSTRACT
A new class of self-assembling peptides with hyaluronic acid-binding domains shows great promise for biomedical applications, particularly in treating injuries, cancer, and enhancing the function of implantable devices. These peptides self-assemble into nanofibers...
Published: 12/11/2025
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Updated: 9/10/2024
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Inventor(s):
Keywords(s): Cancer/Oncology, Drug delivery, Enabling technology, Foreign body response, Implantable devices, Inflammation, Lung disease, Wound healing
Category(s): Life Sciences > Therapeutics
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Therapy for acute kidney injury
NU 2022-202
INVENTORS
Pinelopi Kapitsinou*
Ratnakar Tiwari
SHORT DESCRIPTION
Inhibition of MCT4 slows the progression of acute kidney inury to chronic kidney disease
BACKGROUND
Acute kidney inury (AKI) is a sudden onset of kidney dysfunction, often caused by factors such as ischemia, toxins, or infections, leading to impaired filtration and accumulation...
Published: 2/6/2026
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Updated: 7/10/2024
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Inflammation, Renal Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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Novel Biomarker for Lung Disease Diagnosis and Monitoring
NU2022-232
INVENTORS
Ankit Bharat*
Yuanqing Yan
SHORT DESCRIPTION
A robust and reliable biomarker for diagnosing and predicting lung disease
ABSTRACT
The lack of robust biomarkers for lung diseases is a pressing challenge. A team of scientists at Northwestern University has identified the protein serine protease inhibitor Kazal-type 1 (SPINK1)...
Published: 3/26/2026
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Updated: 2/22/2024
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Inventor(s):
Keywords(s): Cardio-Pulmonary, Diagnostics, Inflammation, Lung disease
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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Novel Therapeutic Target for Treating Lung Disease
NU2022-231
INVENTORS
Ankit Bharat*
Yuanqing Yan
SHORT DESCRIPTION
A novel protein target for treating chronic and acute lung diseases
ABSTRACT
Lung diseases caused by pulmonary fibrosis can be fatal, and the currently approved drugs for treating pulmonary fibrosis, including Nintedanib and Pirfenidone, only slow down the disease progression....
Published: 3/26/2026
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Updated: 2/22/2024
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Inventor(s):
Keywords(s): Cardio-Pulmonary, Inflammation, Lung disease
Category(s): Life Sciences > Therapeutics
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Immunomodulatory Nanoparticles for the Therapeutic Intervention of Traumatic Brain Injury
NU 2019-030
INVENTORS
John Kessler
Sripadh Sharma
ABSTRACT
There is no decisive treatment for traumatic brain injury (TBI). After the primary trauma, secondary injury, largely mediated by blood-borne immune cells called monocytes, takes place causing damage to surrounding healthy cells. Furthermore, cellular and whole brain swelling (edema) resulting...
Published: 1/14/2026
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Updated: 5/27/2022
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Inventor(s):
Keywords(s): Autoimmune disease, CNS - Central Nervous System, Immunology, Inflammation, Neurologic disease, Neurology, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
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