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Incomplete Autophagy Induction for the Treatment of Cancer
SHORT DESCRIPTION
This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival.
INVENTORS
INVENTORS
Maciej Lesniak*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
Jawad...
Published: 5/13/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Autophagy, Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Dual-Action Inhibition Strategy for KRAS and LKB1 Mutant NSCLC
NU 2023-113
INVENTORS
Lillian Eichner (Feinberg School of Medicine, Department of Biochemistry and Molecular Genetics)*
Reuben Shaw (Salk Institute)
SHORT DESCRIPTION
A dual drug combination to target KRAS and LKB1 mutant non–small cell lung cancer that results in superior efficacy by enhancing T cell recruitment and reducing tumor burden.
BACKGROUND
Lung...
Published: 5/26/2026
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Updated: 4/29/2026
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Inventor(s): Reuben Shaw
Keywords(s): Cancer/Oncology, Lung cancer, Repurposed Drugs, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION
Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma.
INVENTORS
Amy Heimberger*
Northwestern University Feinberg School of Medicine, Department of Neurological Surgery
* Principal Investigator
NU Tech ID: NU 2025-212
IP...
Published: 5/7/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
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Targeting IL-6 pathway to treat high risk myelodysplastic syndromes
NU 2022-093
INVENTORS
Peng Ji*
Kehan Ren
Yang Mei
SHORT DESCRIPTION
A method of inhibiting progression of high-risk myelodysplastic syndrome (MDS) or low blast count acute myeloid leukemia (AML) using an inhibitor of IL6 signaling.
BACKGROUND
Approximately 20,000 people in the US are diagnosed with myelodysplastic syndrome (MDS) each year....
Published: 2/17/2026
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Updated: 2/17/2026
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Inventor(s):
Keywords(s): AML - Acute myeloid leukemia, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086
INVENTORS
Atique Ahmed*
Cheol Park
Jack Shireman
SHORT DESCRIPTION
This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs.
BACKGROUND
Glioblastoma is an incurable, aggressive...
Published: 2/6/2026
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Updated: 6/20/2025
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Inventor(s):
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
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Repurposing Bumetanide to Address Cognitive Deficits in Schizophrenia
NU 2019-067
INVENTORS
Herbert Y. Meltzer
SHORT DESCRIPTION
Repurposing bumetaide to treat cognitive deficits in schizophrenia syndrome.
ABSTRACT
Cognitive deficits associated with schizophrenia syndrome are the components that contribute most to a low quality of life. While current pharmacological treatments have beneficial effects on treating...
Published: 5/13/2026
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Updated: 5/30/2023
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Inventor(s):
Keywords(s): Neurologic disease, Neurology, PSD - Psychotic spectrum disorder, Repurposed Drugs, Schizophrenia, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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