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Bioactive Supramolecular Peptide Amphiphile Platforms for CNS In Vitro Models, CNS Regeneration, and Neurotherapeutic Delivery
SHORT DESCRIPTION
A suite of self‑assembling peptide amphiphile nanostructures and hydrogels that mimic key neurotrophic factors, modulate ionic and electrical microenvironments, and protect therapeutic peptides to enhance neural survival, maturation, and regeneration across CNS diseases and injuries
INVENTORS
Samuel I Stupp
Weinberg...
Published: 6/2/2026
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Updated: 6/2/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, Biomaterials, CNS - Central Nervous System, Drug delivery, Drug discovery, Drug screening, Hydrogel, In vitro models, Neurology, PD - Parkinson's Disease, Regenerative medicine, Research tool, Scaffold, SCI - Spinal cord injury, Smart/Functional materials, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
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Micro-Ovary: A Self-Assembled Ovary at Microscale Resolution
fidelity drug screening and reproductive applications.
INVENTORS
Francesca Duncan*
Aubrey Converse
Lauren Haky
* Principal Investigator
NU Tech ID: NU 2025-292
IP STATUS
Pending
DEVELOPMENT STAGE
TRL-4 Prototype Validated in Lab: Self-assembly and follicle encapsulation have been demonstrated...
Published: 6/2/2026
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Updated: 6/2/2026
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Inventor(s):
Keywords(s):
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
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Novel Aminotransferase Inhibitor Platform for the Treatment of Cancer and Neurological Disorders
SHORT DESCRIPTION
Novel Aminotransferase Mechanism-Based Inhibitor (MBI) Platform Targeting OAT and GABA-AT as Novel Treatments for Cancer and Neurological Disorders.
INVENTORS
Richard Silverman*
Weinberg College of Arts and Sciences, Department of Chemistry
* Principal Investigator
DEVELOPMENT...
Published: 6/1/2026
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Updated: 6/1/2026
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Inventor(s):
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Epilepsy, Gastric cancer, Liver cancer, Lung cancer, Neurodegenerative disease, Neurologic disease, Neurology, Pancreatic cancer, PD - Parkinson's Disease, Psychiatric disorder, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Fatty-Acid Modified Cytotoxins and Peptides for Improved Efficacy, Safety, and Dosing Flexibility
SHORT DESCRIPTION
A suite of four complementary technologies for a long-chain fatty‑acid–guided drug delivery platform to achieve superior therapeutic outcomes with reduced toxicity across both oncology and critical care applications.
INVENTORS
Nathan Gianneschi*, and others
Weinberg College of Arts and Sciences,...
Published: 6/2/2026
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Updated: 6/1/2026
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Inventor(s):
Keywords(s): Adjunct therapy, BIO2026, Biologic, Breast cancer, Cancer/Oncology, Chemotherapy, Colon cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Small Molecule Inhibitors of Pleckstrin-2 for Treating Myeloproliferative Neoplasms
SHORT DESCRIPTION
Small molecule inhibitors of Pleckstrin-2 (Plek2) for treating cell proliferative diseases and disorders, particularly myeloproliferative neoplasms (MPNs).
NU Tech IDs: NU 2018-169, NU 2021-005
PRINCIPAL INVESTIGATOR
Peng Ji
Northwestern University Feinberg School of Medicine, Department of Pathology
IP...
Published: 5/27/2026
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Updated: 5/27/2026
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Inventor(s):
Keywords(s): Breast cancer, Cancer/Oncology, Colon cancer, Leukemia, Lung cancer, Pancreatic cancer, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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Safe, Automated, And High Yielding Method For Synthesizing Deoxyoligonucleicguanidines (DNG) Strands
NU 2019-109
SHORT DESCRIPTION
Spherical nucleic acids (SNAs) incorporating deoxynucleic guanidine (DNG)-modified oligonucleotides enable improved cellular uptake and intracellular delivery by introducing positively charged backbone modifications.
BACKGROUND
Oligonucleotide therapeutics, including antisense and RNA interference (RNAi) approaches,...
Published: 5/21/2026
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Updated: 5/18/2026
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Inventor(s):
Keywords(s): Drug delivery, Nucleic Acids, Platform technology, Research tool
Category(s): Life Sciences > Therapeutics
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Piperacillin for Targeted Lyme Disease Treatment
SHORT DESCRIPTION
For infectious disease clinicians, this piperacillin-based therapeutic approach targets Lyme disease by inhibiting bacterial cell wall synthesis to reduce disease progression.
INVENTORS
INVENTORS
Brandon Jutras*
Northwestern University Feinberg School of Medicine, Department of Microbiology-Immunology
...
Published: 6/3/2026
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Updated: 5/18/2026
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Inventor(s):
Keywords(s): Infectious disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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Northwestern Startup: Akava Therapeutics
Founded: 2019
Northwestern Inventor:
Richard Silverman
Weinberg College of Arts and Sciences
Department of Chemistry and Department of Molecular Biosciences
Feinberg School of Medicine
Department of Pharmacology
AKAVA Therapeutics is developing first-in-class small molecule therapeutics that inhibit enzymes, inhibit cancer, and inhibit protein...
Published: 5/13/2026
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Updated: 5/13/2026
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Inventor(s):
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, Neurodegenerative disease, Neurology, Therapeutics
Category(s): Life Sciences > Therapeutics
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Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION
A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure.
INVENTORS
Elizabeth...
Published: 5/15/2026
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Updated: 5/12/2026
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Inventor(s):
Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
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Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance
SHORT DESCRIPTION
A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance.
INVENTORS
Edward Thorp*
Northwestern University Feinberg School of Medicine, Department of Pathology
Evan Scott*
McCormick School of Engineering, Department...
Published: 5/7/2026
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Updated: 5/7/2026
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Inventor(s):
Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation
Category(s): Life Sciences > Therapeutics
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